Recombinant HIV-2 gp36

HIV-2 is a phylogenetic relative of HIV-1, which is reported to be less infectious and induce a slower progression to AIDS than HIV-1. Accordingly, the clinical outcomes and treatment approaches for HIV-1 and HIV-2 infection are different, and distinguishing between the 2 strains is an important diagnostic objective. Despite extensive sequence heterology between HIV-1 and HIV-2, the structures of the HIV-1 and HIV-2 envelope proteins are similar, with HIV-2 gp36 mediating the fusogenic activity of the HIV-2 envelope, and representing the structural and functional equivalent of HIV-1 gp41. The immunodominant regions of gp41 and gp36 are, however, sufficiently distinct such that antibodies generated against HIV-1 and HIV-2 do not cross-react significantly with their respective cognate gp41 and gp36 targets. As such recombinant gp36 is commonly used in diagnostic immunoassays to distinguish between HIV-1 and HIV-2 infections.

Caution: This product is intended for research or manufacturing use only.

Product Details:

Product # BA02-F
Size 1mg
Appearance Colourless liquid
Purity >95%
Mol Weight approx 17.0kDa
Concentration 1.0 mg/ml
Buffer 50mM Formate pH3.0
Activity Binds HIV-2 positive serum antibodies
Shipping Shipped on wet ice
Storage Shipped at ambient temperature,
store at 4ºC, or aliquot and freeze (-20ºC) following reconstitution
avoid repeated freeze-thaw cycles
Expression System E. Coli
Assay Method(s) SDS-PAGE (purity),
Immunoblot (reactivity sera)
Application Suitable for use in ELISA, Western Blot
& lateral flow assays. Each laboratory
should determine optimum working titre
for use in it’s particular application
Expiry Date As indicated
Production Date As indicated
Assay Date As indicated
Lot # As indicated